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PostPosted: Thu Oct 05, 2017 1:39 am
by pknyoike
i have been asked this question severally, but i have no answer on it. Kindly assist

1. Pretransfusion testing results on a patient with a 3-unit crossmatch order are as follows: ABO/Rh :-B-positive; unexpected antibody screen—no unexpected antibodies detected; 3 RBC units crossmatched – unit 1, compatible at AHG; unit 2, compatible at AHG; and unit 3, incompatible at AHG using gel column methodology.
a. What can account for the incompatible unit? Explain?
b. How would you resolve this situation?


PostPosted: Thu Oct 05, 2017 6:18 am
by dkorkowski
Since two of the three units were compatible I would lean towards a low incidence antibody, my initial reaction would be to pull a new unit and test. If the incompatibility continues with additional units, I would perform warm technique testing to see if it was a cold antibody causing the issue.